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KMID : 0359320180580020095
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Korean Journal of Veterinary Research
2018 Volume.58 No. 2 p.95 ~ p.98
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Different invasion efficiencies of Brucella abortus wild-type and mutants in RAW 264.7 and THP-1 phagocytic cells and HeLa non-phagocytic cells
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Shim Soo-Jin
Im Young-Bin
Jung Myung-Hwan
Park Woo-Bin
Yoo Han-Sang
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Abstract
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Brucellosis is one of the common zoonoses caused by Brucella abortus (B. abortus). However, little has been reported on factors affecting invasion of B. abortus into host cells. To investigate cell-type dependent invasion of B. abortus, phagocytic RAW 264.7 and THP-1 cells and non-phagocytic HeLa cells were infected with wild-type and mutant B. abortus, and their invasion efficiencies were compared. The invasion efficiencies of the strains were cell-type dependent. Wild-type B. abortus invasion efficiency was greater in phagocytic cells than in epithelial cells. The results also indicated that there are different factors involved in the invasion of B. abortus into phagocytic cells.
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KEYWORD
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Brucella abortus, cell invasion, mutants, non-phagocytes, phagocytes
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